Premium
Magnetic resonance imaging of inflammatory bowel disease: Evaluation in a rabbit model
Author(s) -
Knollmann Friedrich D.,
Dietrich Thore,
Bleckmann Tim,
Böck Johannes,
Mäurer Jürgen,
Radtke Cornelia,
Felix Roland
Publication year - 2002
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.10054
Subject(s) - gadodiamide , inflammatory bowel disease , medicine , magnetic resonance imaging , ulcerative colitis , inflammation , pathology , gastroenterology , thickening , radiology , disease , chemistry , polymer science
Purpose To correlate intestinal contrast enhancement and wall thickening with the degree of inflammation in an experimental model of inflammatory bowel disease. Materials and Methods Inflammatory bowel disease was elicited in 39 New Zealand White rabbits by rectal instillation of 2,4,6‐trinitrobenzene sulphonic acid (TNBA). Magnetic resonance imaging (MRI) was used to determine bowel wall thickness and intestinal contrast enhancement after the administration of 0.1 mmol/kg of gadodiamide intravenously. MR measurements were compared with the complete histopathologic analysis. Results MR measurements of bowel wall thickness correlated well with histopathologic measurements in vitro (r = 0.85, P < 0.0001) and with histopathologic evidence of chronic inflammatory bowel disease ( P < 0.02). Chronic inflammation was characterized by increased intestinal contrast enhancement (137 ± 25%) when compared to normal bowel (86 ± 7%, P = 0.04). Conclusion Contrast‐enhanced MRI accurately reflects inflammatory bowel disease in the rabbit model. J. Magn. Reson. Imaging 2002;15:165–173. © 2002 Wiley‐Liss, Inc.