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FAST sequences optimization for contrast media pharmacokinetic quantification in tissue
Author(s) -
Ivancevic Marko K.,
Zimine Ivan,
Lazeyras François,
Foxall David,
Vallée JeanPaul
Publication year - 2001
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.10009
Subject(s) - flip angle , contrast (vision) , sensitivity (control systems) , nuclear magnetic resonance , sequence (biology) , dynamic range , flash (photography) , magnetic resonance imaging , dynamic contrast , dynamic contrast enhanced mri , materials science , physics , chemistry , optics , medicine , radiology , electronic engineering , biochemistry , engineering
Abstract The purpose of this study was to investigate the influence of the fast gradient‐recalled echo (GRE) sequence parameters on the contrast dynamic range and signal sensitivity, to optimize the magnetic resonance (MR) sequence for contrast media pharmacokinetic assessment. Effects of the fast low‐angle shot (FLASH), Fast acquisition at steady rate (FAST), and radiofrequency‐spoiled (RF)‐FAST sequence parameters were studied in vitro. The FAST sequence had the highest sensitivity in low gadolinium (Gd) concentration. The FLASH and RF‐FAST sequences had a larger contrast dynamic range, but the FLASH images contained side band artifacts. Increasing the flip angle to 90° raised the sensitivity of the FAST sequence and the contrast dynamic range of the RF‐FAST sequence. The shortest possible TE was optimal for both contrast dynamics and imaging time. TI had an influence on the sensitivity of the FAST sequence only for small acquisition matrices. This study indicates the optimal parameters for contrast dynamics (RF‐FAST, 90° flip angle, shortest possible TE) and sensitivity (FAST, 90° flip angle, long TI eff ). J. Magn. Reson. Imaging 2001;14:771–778. © 2001 Wiley‐Liss, Inc.