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Interchromatidal central ridge and transversal symmetry in early metaphasic human chromosome one
Author(s) -
ArgüelloMiranda Orlando,
SáenzArce Giovanni
Publication year - 2008
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.884
Subject(s) - transversal (combinatorics) , ridge , metaphase , chromosome , symmetry (geometry) , euchromatin , optics , biology , heterochromatin , anatomy , physics , geometry , paleontology , mathematics , genetics , mathematical analysis , gene
The topographic structure of Giemsa‐banded (G‐banded) early metaphase human chromosomes adsorbed on glass was analyzed by atomic force microscope using amplitude modulation mode (AM‐AFM). Longitudinal height measurements for early metaphasic human chromosomes showed a central ridge that was further characterized by transversal height measurements. The heterochromatic regions displayed a high level of transversal symmetry, while the euchromatic ones presented several peaks across the transversal height measurements. We suggest that this central ridge and symmetry patterns point out a transitional arrangement of the early metaphase chromosome and support evidence for interchromatidal interactions prior to disjunction. Copyright © 2008 John Wiley & Sons, Ltd.