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An AFM study on mechanical properties of native and dimethyl suberimidate cross‐linked pericardium tissue
Author(s) -
Matyka K.,
Matyka M.,
Mróz I.,
ZalewskaRejdak J.,
Ciszewski A.
Publication year - 2007
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.855
Subject(s) - atomic force microscopy , stiffness , chemistry , native tissue , modulus , pericardium , biophysics , materials science , nanotechnology , composite material , tissue engineering , biomedical engineering , surgery , biology , medicine
Abstract Changes in the stiffness of hog pericardium tissue, native and treated with dimethyl suberimidate (DMS), are investigated by atomic force microscopy (AFM). Young's modulus is calculated on the basis of the Hertz–Sneddon model. The cross‐linking process increases the stiffness of the tissue. The values of Young's modulus are higher for the DMS stabilized pericardium than for the native one. We also observe that the Young's modulus of native tissue increases when the time between getting the biological material and performing the measurements is longer. This process is probably connected with natural degradation of the biological samples. Copyright © 2007 John Wiley & Sons, Ltd.