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Towards a consensus on datasets and evaluation metrics for developing B‐cell epitope prediction tools
Author(s) -
Greenbaum Jason A.,
Andersen Pernille Haste,
Blythe Martin,
Bui HuynhHoa,
Cachau Raul E.,
Crowe James,
Davies Matthew,
Kolaskar A. S.,
Lund Ole,
Morrison Sherrie,
Mumey Brendan,
Ofran Yanay,
Pellequer JeanLuc,
Pinilla Clemencia,
Ponomarenko Julia V.,
Raghava G. P. S.,
van Regenmortel Marc H. V.,
Roggen Erwin L.,
Sette Alessandro,
Schlessinger Avner,
Sollner Johannes,
Zand Martin,
Peters Bjoern
Publication year - 2007
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.815
Subject(s) - epitope , computer science , set (abstract data type) , epitope mapping , computational biology , data science , theme (computing) , data mining , antigen , immunology , biology , world wide web , programming language
A B‐cell epitope is the three‐dimensional structure within an antigen that can be bound to the variable region of an antibody. The prediction of B‐cell epitopes is highly desirable for various immunological applications, but has presented a set of unique challenges to the bioinformatics and immunology communities. Improving the accuracy of B‐cell epitope prediction methods depends on a community consensus on the data and metrics utilized to develop and evaluate such tools. A workshop, sponsored by the National Institute of Allergy and Infectious Disease (NIAID), was recently held in Washington, DC to discuss the current state of the B‐cell epitope prediction field. Many of the currently available tools were surveyed and a set of recommendations was devised to facilitate improvements in the currently existing tools and to expedite future tool development. An underlying theme of the recommendations put forth by the panel is increased collaboration among research groups. By developing common datasets, standardized data formats, and the means with which to consolidate information, we hope to greatly enhance the development of B‐cell epitope prediction tools. Copyright © 2007 John Wiley & Sons, Ltd.