Premium
High‐resolution crystallography and drug design
Author(s) -
Cachau R. E.,
Podjarny A. D.
Publication year - 2005
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.738
Subject(s) - resolution (logic) , high resolution , function (biology) , low resolution , nanotechnology , computer science , chemistry , data science , materials science , biology , artificial intelligence , geography , remote sensing , evolutionary biology
Ultra‐high‐resolution X‐ray crystallography of macromolecules (i.e. resolution better than 0.8 Å) is a rising field that promises to provide new insight into the structure–function relationships of biomacromolecules. The picture emerging from macromolecular structures at this resolution is far more complex than previously understood, requiring for its study improved tools for structure refinement, analysis and annotation. Some of these problems were highlighted during the recent High Resolution Drug Design Meeting (Bischenberg‐Strasbourg, France, 13–16 May 2004). We will review here some of the results and discussions that took place during that meeting and elaborate on the trends and challenges ahead in this emerging new field of research. Copyright © 2005 John Wiley & Sons, Ltd.