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Drug targeting by macromolecules without recognition unit?
Author(s) -
Hudecz Ferenc,
Reményi Judit,
Szabó Rita,
Kóczán György,
Mező Gábor,
Kovács Péter,
Gaál Dezső
Publication year - 2003
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.639
Subject(s) - conjugate , macromolecule , endocytosis , chemistry , biochemistry , methotrexate , receptor , biology , immunology , mathematical analysis , mathematics
his review will summarize available information on the ability of macromolecular conjugates containing no specific recognition motifs to deliver anthracyclines (daunomycin, adriamycin) or methotrexate to target cells such as tumour cells or macrophages. Conjugates with natural (proteins, DNA, carbohydrates) and synthetic macromolecules (linear and branched chain poly‐α‐amino acids, non‐biodegradable DIVEMA, HPMA etc.) will be reviewed. Experimental data from several laboratories indicate that these conjugates are taken up by cells mainly by fluid‐phase or adsorptive endocytosis. It is believed that these processes do not involve ‘specific receptors’. Two examples of methotrexate and daunomycin conjugates will be discussed to show the effect of the chemical structure of branched chain polypeptides on the uptake and antitumour or antiparasitic ( Leishmania donovani infection) efficacy of conjugates. Copyright © 2003 John Wiley & Sons, Ltd.