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Synthesis and application of functional peptides as cell nucleus‐directed molecules in the treatment of malignant diseases
Author(s) -
Pipkorn R.,
Waldeck W.,
Braun K.
Publication year - 2003
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.632
Subject(s) - peptide , transmembrane protein , computational biology , cell , chemistry , drug discovery , biochemistry , biomolecule , function (biology) , drug development , nucleus , small molecule , biology , microbiology and biotechnology , drug , receptor , pharmacology
The unique functions of biomolecules, including transport accross biological membranes (e.g. the cell membrane, the nuclear envelope), modulation of protein function, gene transcription, reconstitution of the malignant transformation, and viral, bacterial and fungal activities underlie a high pharmaceutical potential. The development of combinatorial functional peptide modules in this important area has been slow, in contrast to the rapid development in the synthesis of small biopolymers. The conjugation of a short transmembrane transport peptide module with a cell nucleus address peptide module and with any substance is attractive for preparation of BioShuttle‐based peptides because of the well‐established automated synthesis of peptides. Variation of the different functional modules for drug targeting and the choice of substances can be combined to create novel bioconjugates with unique properties. This article provides an overview of previous work on the BioShuttle technology and outlines the promising use of this approach in combinatorial peptide synthesis and drug discovery. Copyright © 2003 John Wiley & Sons, Ltd.