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Blocking of CD4 cell receptors for the human immunodeficiency virus type 1 (HIV‐1) by chemically modified bovine milk proteins: Potential for AIDS prophylaxis
Author(s) -
Neurath A. Robert,
Debnath Asim K.,
Strick Nathan,
Li YunYao,
Lin Kang,
Jiang Shibo
Publication year - 1995
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.300080504
Subject(s) - bovine serum albumin , chemistry , receptor , viral envelope , trimellitic anhydride , glycoprotein , gp41 , biochemistry , chemical modification , serum albumin , virology , biology , antibody , immunology , epitope , organic chemistry
The chemical transformation of synthetic combinatorial libraries to increase the diversity of compounds of medicinal interest was reported recently. Chemical modification of natural products represents a complementary approach to accomplish this aim. Modification of lysines by aromatic acid anhydrides, preferentially by 3‐hydroxyphthalic and trimellitic anhydrides and trimellitic anhydride chloride, converted commonly available proteins (human and bovine serum albumin and casein) into potent inhibitors of (i) binding between the HIV‐1 gp120 envelope glycoprotein and the CD4 cell receptor, probably owing to their binding to CD4, and (ii) infection by HIV‐1. Modified bovind milk proteins are also potent HIV‐1 inhibitors and may have protential for anti‐Hiv‐1 prophylaxis.