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Immunoglobulin‐like domain is present in the extracellular part of the receptor tyrosine kinase from the marine sponge geodia cydonium
Author(s) -
Schäcke Heike,
Rinkevich Baruch,
Gamulin Vera,
Müller Isabel M.,
Müller Werner E. G.
Publication year - 1994
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.300070406
Subject(s) - sponge , immunoglobulin domain , biology , receptor tyrosine kinase , tyrosine , tyrosine kinase , antibody , protein kinase domain , receptor , homology (biology) , amino acid , microbiology and biotechnology , biochemistry , genetics , gene , botany , mutant
We have isolated and characterized two cDNAs from the marine sponge Geodia cydonium coding for a new member of a receptor tyrosine kinase of class II. The deduced amino acid sequence shows two characteristic domains: (i) the tyrosine kinase domain; and (ii) and immunoglobulin‐like domain. The latter part shows high homology to the vertebrate C2 type immunoglobulin domain. This result demonstrates that immunoglobulin domains are not recent achievements of higher animals but exist also in those animals which have diverged from other organisms about 800 million years ago.