Premium
Identification of a pharmacophore for nucleoside analog inhibitors directed at HIV‐1 reverse transcriptase
Author(s) -
Fisher Mark A.,
Yadav Prem N. S.,
Yadav Janardan,
Kristol David,
Arnold Edward,
Modak Mukund J.
Publication year - 1994
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.300070309
Subject(s) - pharmacophore , reverse transcriptase , identification (biology) , human immunodeficiency virus (hiv) , nucleoside reverse transcriptase inhibitor , chemistry , nucleoside analogue , nucleoside , virology , computational biology , combinatorial chemistry , stereochemistry , biochemistry , medicine , biology , rna , botany , gene
An ‘active analog’ approach to receptor mapping was used to identify a pharmacophore for a set of thymidine nucleoside analog inhibitors of HIV‐1 reverse transcriptase. The preliminary results indicate that the O2, O4′, and O5′ atoms are capable of adopting a unique pharmacophoric pattern which may be the key to their recognition by reverse transcriptase.