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The design and synthesis of mimetics of peptide β‐turns
Author(s) -
Kahn Michael,
Wilke Susanne,
Chen Barbara,
Fujita Kagari,
Lee YuHwei,
Johnson Michael E.
Publication year - 1988
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.300010205
Subject(s) - peptide , combinatorial chemistry , chemistry , stereochemistry , biochemistry
The synthesis of an 11 membered ring bis‐lactam, a system which is designed as a conformationally restricted mimetic of type I and II β‐turns is described. Computer assisted molecular modeling was used to compare the predicted low energy conformers of the turn mimetic with idealized type I and type II turn structures. Initial computation analysis indicates that the basic ring structure will provide an excellent foundation for the development of variety of β‐turn mimetics.