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Utilization of rGO‐PEI‐ supported AgNPs for sensitive recognition of deltamethrin in human plasma samples: A new platform for the biomedical analysis of pesticides in human biofluids
Author(s) -
Adel Bashir,
Jafari Mohsen,
Hasanzadeh Mohammad
Publication year - 2021
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.2900
Subject(s) - differential pulse voltammetry , graphene , silver nanoparticle , detection limit , polyethylenimine , cyclic voltammetry , materials science , nanotechnology , substrate (aquarium) , chemistry , nuclear chemistry , nanoparticle , chromatography , electrode , electrochemistry , biochemistry , oceanography , gene , geology , transfection
In this study, the rGO‐PEI‐AgNPs sensor was designed as a new effective platform to sensitive monitoring of deltamethrin in human plasma samples. For this purpose, reduced graphene oxide (rGO)‐supported polyethylenimine (PEI) was used as a suitable substrate for dispersion of silver nanoparticles (AgNPs) as amplification and catalytic element. Therefore, a novel interface (rGO‐PEI‐AgNPs) was prepared by the fully electrochemical method on the surface of glassy carbon electrodes. The engineered nano‐sensor showed a wide dynamic range of 10 nM to 1 mM and low limit of quantification (LLOQ) as 10 nM in human plasma sample, which revealed excellent analytical performance for the recognition of deltamethrin with high sensitivity and reproducibility through differential pulse voltammetry and square wave voltammetry techniques. The results confirm that rGO‐PEI‐AgNPs as a novel biocompatible interface can provide appropriate, reliable, affordable, rapid, and user‐friendly diagnostic tools in the detection of deltamethrin in human real samples.