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Conditioning adhesive contacts between the neutrophils and the endotheliocytes by S taphylococcus aureus
Author(s) -
Pleskova Svetla.,
Kriukov Ruslan N.,
Bobyk Sergey Z.,
Boryakov Alexey V.,
Gorelkin Peter V.,
Erofeev Alexander S.
Publication year - 2020
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.2846
Subject(s) - adhesion , membrane , chemistry , biophysics , staphylococcus aureus , intracellular , adhesive , force spectroscopy , atomic force microscopy , materials science , nanotechnology , biochemistry , biology , bacteria , genetics , organic chemistry , layer (electronics)
We have developed a model for evaluating the integral intercellular interactions in the “endotheliocyte‐neutrophil” system and have shown the high variability of adhesion contacts in different donors associated with different expression profiles of neutrophils. Two methods (forсe spectroscopy‐spectroscopy and scanning ion‐conductance microscopy) showed a decrease in the rigidity of the membrane‐cytoskeletal complex of neutrophils under the influence of Staphylococcus aureus 2879 M. Adding this strain to the “endotheliocyte‐neutrophil” system caused a statistically significant decrease in the adhesion force and adhesion work, which indicates a change in the expression profile and physicochemical properties of membranes of both types of interacting cells (neutrophils and endotheliocytes).