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The multiple flavors of GoU pairs in RNA
Author(s) -
Westhof Eric,
Yusupov Marat,
Yusupova Gulnara
Publication year - 2019
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.2782
Subject(s) - translation (biology) , molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , watson , ribosomal rna , rna , physics , crystallography , biology , chemistry , base pair , genetics , computer science , dna , natural language processing , messenger rna , gene
Wobble GU pairs (or GoU) occur frequently within double‐stranded RNA helices interspersed within the standard G═C and A─U Watson‐Crick pairs. However, other types of GoU pairs interacting on their Watson‐Crick edges have been observed. The structural and functional roles of such alternative GoU pairs are surprisingly diverse and reflect the various pairings G and U can form by exploiting all the subtleties of their electronic configurations. Here, the structural characteristics of the GoU pairs are updated following the recent crystallographic structures of functional ribosomal complexes and the development in our understanding of ribosomal translation.