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Enhanced adhesion of Streptococcus mutans to hydroxyapatite after exposure to saliva
Author(s) -
Spengler Christian,
Thewes Nicolas,
Nolle Friederike,
Faidt Thomas,
Umanskaya Natalia,
Hannig Matthias,
Bischoff Markus,
Jacobs Karin
Publication year - 2017
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.2615
Subject(s) - streptococcus mutans , saliva , adhesion , dentistry , microbiology and biotechnology , chemistry , medicine , biology , bacteria , genetics , biochemistry , organic chemistry
Streptococcus mutans cells form robust biofilms on human teeth and are strongly related to caries incidents. Hence, understanding the adhesion of S. mutans in the human oral cavity is of major interest for preventive dentistry. In this study, we report on atomic force microscopy–based single‐cell force spectroscopy measurements of S. mutans cells to hydroxyapatite surfaces. We observe for almost all measurements a significant difference in adhesion strength for S. mutans as well as for Staphylococcus carnosus cells. However, the increase in adhesion strength after saliva exposure is much higher for S. mutans cells compared to S. carnosus cells. Our results demonstrate that S. mutans cells are well adapted to their natural environment, the oral cavity. This ability promotes the biofilm‐forming capability of that species and hence the production of caries‐provoking acids. In consequence, understanding the fundamentals of this mechanism may pave a way towards more effective caries‐reducing techniques.