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Evaluation of electrochemically synthesized sulfadimethoxine‐imprinted polymer for solid‐phase microextraction of sulfonamides
Author(s) -
DíazÁlvarez Myriam,
Mazzotta Elisabetta,
Malitesta Cosimino,
MartínEsteban Antonio
Publication year - 2014
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.2362
Subject(s) - sulfadimethoxine , solid phase microextraction , molecularly imprinted polymer , ethylene glycol dimethacrylate , differential pulse voltammetry , ethylene glycol , molecular imprinting , extraction (chemistry) , chemistry , polypyrrole , pyrrole , polymer , cyclic voltammetry , chromatography , materials science , copolymer , organic chemistry , electrochemistry , selectivity , electrode , gas chromatography–mass spectrometry , catalysis , mass spectrometry , methacrylic acid , polymerization
Solid‐phase microextraction (SPME) is widely used in analytical laboratories for the analysis of organic compounds, thanks to its simplicity and versatility. In the present work, the synthesis and evaluation of imprinted films for SPME by electropolymerisation of pyrrole alone or in the presence of ethylene glycol dimethacrylate is proposed. Sulfadimethoxine (SDM), a sulfonamide antibiotic, was used as template molecule. Initially, a molecularly imprinted polymer film was prepared by electropolymerisation of pyrrole onto a platinum foil, using SDM as template. The SDM template was removed by overoxidation. The behaviour of SDM on imprinted and non‐imprinted polymers was investigated by differential pulse voltammetry, and a clear imprinting effect was observed, which was confirmed by rebinding experiments using both conventional and electrochemically enhanced‐SPME. However, in general, the extraction efficiency was rather low (<6%) and unspecific interactions are too high. Attempts to increase extraction efficiency were unsuccessful, but the incorporation of ethylene glycol dimethacrylate to the films reduced unspecific interactions to a certain extent. Copyright © 2014 John Wiley & Sons, Ltd.