Premium
Polyamide recognition‐mass spectrometry for distinguishing hairpin DNA from coil DNA
Author(s) -
Zheng Bo,
Liu Yiquan,
Yuan Gu
Publication year - 2011
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.1149
Subject(s) - electrospray ionization , dna , polyamide , chemistry , mass spectrometry , chromatography , polymer chemistry , biochemistry
The discrimination between hairpin DNA and coil DNA has been well achieved through polyamides as probes by electrospray ionization (ESI) mass spectrometry. ESI mass spectra showed that polyamides bind to hairpin DNA with high selectivity, and almost no binding with coil DNA. In addition, the noncovalent interaction between polyamides and hairpin DNA was also studied; the results show that hairpin DNA with longer stem and polyamides with more heterocycles have higher binding affinity and stability in gas phase. Copyright © 2011 John Wiley & Sons, Ltd.