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Nuclear delivery mechanism of herpes simplex virus type 1 genome
Author(s) -
Liashkovich Ivan,
Hafezi Wali,
Kühn Joachim M,
Oberleithner Hans,
Shahin Victor
Publication year - 2011
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.1120
Subject(s) - capsid , herpes simplex virus , genome , virology , biology , virus , population , nuclear pore , viral replication , computational biology , mechanism (biology) , microbiology and biotechnology , gene , genetics , cytoplasm , physics , medicine , environmental health , quantum mechanics
Abstract Herpes simplex virus type 1 (HSV‐1) is a widespread human pathogen infecting more than 80% of the population worldwide. Its replication involves an essential, poorly understood multistep process, referred to as uncoating. Uncoating steps are as follows: (1) The incoming capsid pinpoints the nuclear pore complex (NPC). (2) It opens up at the NPC and releases the highly pressurized viral genome. (3) The viral genome translocates through the NPC. In the present review, we highlight recent advances in this field and propose mechanisms underlying the individual steps of uncoating. We presume that the incoming HSV‐1 capsid pinpoints the NPC by hydrophobic interactions and opens up upon binding to NPC proteins. Genome translocation is initially pressure‐driven. Copyright © 2011 John Wiley & Sons, Ltd.