Premium
Amino acids binding to Zn 2+ ‐cyclen molecular receptor in aqueous solution
Author(s) -
Vargová Z.,
Balentová E.,
Walko M.,
Arabuli L.,
Hermann P.,
Lukeš I.
Publication year - 2011
Publication title -
journal of molecular recognition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.401
H-Index - 79
eISSN - 1099-1352
pISSN - 0952-3499
DOI - 10.1002/jmr.1059
Subject(s) - chemistry , cyclen , amino acid , denticity , potentiometric titration , deprotonation , stereochemistry , stability constants of complexes , amine gas treating , carboxylate , alanine , aqueous solution , titration , glycine , medicinal chemistry , metal , organic chemistry , biochemistry , ion
Abstract Potentiometric titrations and 1 H NMR spectroscopic studies of amino acids binding to the [ZnL] 2+ ‐complex where L = cyclen in aqueous solution provide information concerning complexing species identity, their stability, and coordination mode declaration. The amino acids form stable ternary [ZnL(HL n )] 2+ and [ZnL(L n )] + complexes. The observations indicate bidentate coordination mode of the deprotonated amino acids, involving both the amine and the carboxylate functions to the [ZnL] 2+ complex in pH region of about 7.5–9.5. The determined stability constants indicate that [ZnL] 2+ complex is a very efficient receptor for simple amino acids such as glycine and alanine. Copyright © 2010 John Wiley & Sons, Ltd.