Premium
The development of the septum primum relative to atrial septation in the mouse heart
Author(s) -
Dalgleish Arthur E.
Publication year - 1976
Publication title -
journal of morphology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 74
eISSN - 1097-4687
pISSN - 0362-2525
DOI - 10.1002/jmor.1051490306
Subject(s) - primary interatrial foramen , septum secundum , anatomy , interatrial septum , sinus venosus , atrioventricular cushions , fossa ovalis , foramen secundum , biology , medicine , patent foramen ovale , heart disease , left atrium , migraine , atrial fibrillation
The septum primum in the mouse originates as a thickened primordium with a straight rather than a sickle‐shaped ventral border. It is covered on its ventral border by anterior cushion material which is continuous over the roof of the atrium with the principal anterior cushion mass. A process of cavitation thins the septum primum and precedes actual fenestration. This process shifts the membranous septum to the left thereby providing room for the septum secundum to overlap on the right side. The septum primum cannot contact the posterior cushion until closure of the sinus venosus gutter which is described. The closure of the interatrial foramen, later the foramen primum, is accomplished by cell growth of the anterior cushion material. The ventral thick border of the septum primum contributes to the ventral limbus and the caudal thickened boundary of the fossa ovalis with some contribution from the left venous valve. These boundaries as well as the membranous portion of the interatrial septum are derived from the same primordium, namely the septum primum.