Premium
Assay of cyclic 3′‐5′‐monophosphate in the regenerating forelimb of the newt, Triturus
Author(s) -
Jabaily Joseph,
Rall Theodore W.,
Singer Marcus
Publication year - 1975
Publication title -
journal of morphology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 74
eISSN - 1097-4687
pISSN - 0362-2525
DOI - 10.1002/jmor.1051470402
Subject(s) - forelimb , triturus , biology , regeneration (biology) , anatomy , caudata , cyclic adenosine monophosphate , endocrinology , medicine , biochemistry , microbiology and biotechnology , receptor
Abstract The cyclic adenosine 3′‐5′‐monophosphate content of four regenerate stages in the forelimb of the newt, Triturus viridescens , was assayed using the Gilman method and compared to the content in the normal, unamputated, forelimb. The concentration was found to be highest in the earliest stages of regeneration, followed by a sharp drop and then a rise to a plateau approximately that of the unamputated limb. The possibility that cyclic AMP acts as a second messenger for nervous and hormonal influences on regeneration is discussed.