Premium
Effects of growth hormone and nutrient on limb regeneration in hypophysectomized adult newts
Author(s) -
Sato Norimitsu L.,
Inoue Sakae
Publication year - 1973
Publication title -
journal of morphology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 74
eISSN - 1097-4687
pISSN - 0362-2525
DOI - 10.1002/jmor.1051400408
Subject(s) - hypophysectomy , biology , triturus , regeneration (biology) , medicine , endocrinology , blastema , hormone , growth hormone , anatomy , microbiology and biotechnology
The effect of hypophysectomy, growth hormone (GH) and an amino acid‐glucose mixture on the regenerative ability of the hypophysectomized Triturus pyrrhogaster yielded the following results: 1 The survival time of hypophysectomized newts can be prolonged substantially by the sulfamide application. 2 Although the limb regeneration in the hypophysectomized newt is retarded as compared with that of the pituitary intact control, it finally completes morphogenetic process under such conditions of prolonged survival. 3 The injection of 100 μg of GH restored the speed of regeneration of pituitary‐deprived limbs to almost a normal level. 4 Injections of the amino acid‐glucose mixture also promoted the limb regeneration in hypophysectomized newts. However, initial delay in regeneration to the time of bud appearance was not restored by the nutrients.