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A light microscopic study of the mononuclear cells infiltrating skin homografts in the garter snake, Thamnophis sirtalis (Reptilia: Colubridae)
Author(s) -
Terebey Nicholas
Publication year - 1972
Publication title -
journal of morphology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 74
eISSN - 1097-4687
pISSN - 0362-2525
DOI - 10.1002/jmor.1051370203
Subject(s) - thamnophis sirtalis , colubridae , biology , peripheral blood mononuclear cell , infiltration (hvac) , mononuclear cell infiltration , pathology , zoology , immunology , medicine , biochemistry , physics , in vitro , thermodynamics
Abstract The rejection of skin homografts in the snake, Thamnophis sirtalis is preceded by an infiltration of mononuclear cells into the graft bed. The initial arrangement of infiltrating cells in perivascular halos suggests that these cells emigrate from the blood stream of the host. A cytological study showed that the vast majority of the cells can be classified as small and mediumsized lymphocytes, monocytes and macrophages. Early stages of infiltration were associated with large proportions of lymphocytes while later stages were characterized by a predominance of macrophages. It was concluded that the mononuclear cells associated with graft rejection include large proportions of lymphocytes and macrophages and not just one kind of lymphoid cell.