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Macrophage activity in wolffian lens regeneration
Author(s) -
Yamada T.,
Dumont James N.
Publication year - 1972
Publication title -
journal of morphology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 74
eISSN - 1097-4687
pISSN - 0362-2525
DOI - 10.1002/jmor.1051360309
Subject(s) - melanosome , biology , infiltration (hvac) , microbiology and biotechnology , epithelium , macrophage , cytoplasm , cell type , mesonephric duct , immune system , pinocytosis , pathology , cell , anatomy , melanin , immunology , endocytosis , kidney , endocrinology , medicine , in vitro , biochemistry , physics , genetics , thermodynamics
The cell type mainly involved in the phagocytic uptake of melanosomes from iris epithelial cells during Wolffian lens regeneration in the adult newt is identified on the basis of electron and light microscopic evidence as a macrophage of monocytic origin. Appearance of macrophages in iris and ciliary epithelia following lentectomy is a part of leucocytic infiltration of the area, in which granulocytes, mast cells, and other cell types also participate. The general pattern of leucocytic infiltration was studied as a function of time after lentectomy. Infiltration of the iris epithelium by macrophages is reduced when most of the melanosomes have been removed from the cytoplasm of the epithelial cells and finally ceases when depigmentation has been completed. The possibility that an immune mechanism mediated by macrophages is involved in dedifferentiation of iris epithelial cells is discussed.