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Morphogenetic studies of the rabbit. XL. Growth gradient interaction and function in morphology
Author(s) -
Sawin P. B.,
Hamlet Martha
Publication year - 1970
Publication title -
journal of morphology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 74
eISSN - 1097-4687
pISSN - 0362-2525
DOI - 10.1002/jmor.1051300402
Subject(s) - biology , gene dosage , genetics , epigenetics , gene , genome , anatomy , microbiology and biotechnology , gene expression
I n continuing study of gene and genome interaction as a possible etiological mechanism in normal and abnormal growth and malformation, the ventral spinous processes (VSPs, crural insertions of the diaphragm) were used as additional epigenetic variants to portray differences in the basic gradient growth pattern. Over 700 comparisons of mean differences in number (range or magnitude) and peak (position) of the VSP gradient, in the same populations of strains III, DA, and III Da (into which the Da gene had been introduced from strain DA), provided populations of +/+, Da/+ and Da/Da on two different genome backgrounds. They reveal the individual effects on the VSPs of underlying growth processes associated with the Da gene dosage, vertebral border shifts and stillbirths. Both Da and stillbirths demonstrate growth influences which interact additively to reduce the range and shift the peak anteriorly in opposition to those of the border shifts. The growth effects induced by border shifts are in some cases significantly so much greater as to seemingly inhibit or even reverse either the specific gene Da or stillbirth effects. The way that interaction of such growth influences can enhance, suppress or cancel each other and the relation to specific growth gradients and functions is of particular importance to understanding the etiology and growth mechanisms of spontaneous and unexpected exogenously or endogenously induced malformations in non‐isogenic stocks.