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Electron microscopy of the normal and I 131 treated thyroid gland of the newt, Notophthalmus viridescens
Author(s) -
Hearing Vincent J.,
Eppig Jr. John J.
Publication year - 1969
Publication title -
journal of morphology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 74
eISSN - 1097-4687
pISSN - 0362-2525
DOI - 10.1002/jmor.1051280306
Subject(s) - ultrastructure , golgi apparatus , notophthalmus viridescens , biology , endoplasmic reticulum , electron microscope , thyroid , vacuole , cytoplasm , anatomy , endocrinology , microbiology and biotechnology , physics , regeneration (biology) , optics
The fine structure of the thyroid of the newt, Notophthalmus viridescens , was studied with the electron microscope. Specimens were injected I.P. with 30 μc of I 131 and sample thryoids were examined at 12 hour intervals thereafter. The ultrastructure of the normal thyroid gland is described, and compared with that of the irradiated glands. The first visible ultrastructural change observed after injection of the radioiodin was a striking alteration of nuclear morphology. This effect was followed by an increase in the frequency of whorled lamellar structures, a decrease in the number of microvilli, and degeneration of the Golgi apparatus and endoplasmic reticulum. Further effects observed included an increase in the number of large cytoplasmic granules and a decrease in the number of smaller ones, the presence of autophagic vacuoles, and finally, an increase in the number of degenerated mitochondria.