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The effects of thiourea and cortisone acetate on duodenal length and diameter and on morphogenesis of duodenal villi in chick embryos
Author(s) -
Stocum David L.
Publication year - 1966
Publication title -
journal of morphology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 74
eISSN - 1097-4687
pISSN - 0362-2525
DOI - 10.1002/jmor.1051180204
Subject(s) - morphogenesis , incubation , biology , embryo , duodenum , thiourea , cortisone acetate , cortisone , endocrinology , medicine , anatomy , in ovo , microbiology and biotechnology , biochemistry , chemistry , organic chemistry , gene
Subnormal growth in length and diameter of the duodenum is encountered both in chick embryos injected with thiourea at 11 days of incubation, and in embryos injected with cortisone acetate at 14 days of incubation. Morphogenesis of previllous ridges and villi is retarded in thiourea‐treated embryos. Morphogenesis of previllous ridges and villi in cortisone acetate‐treated embryos at first seems to be slightly accelerated over that of controls, but the acceleration does not appear to be maintained, and the hormone may actually be inhibitory to normal morphogenesis of villi by 19 days of incubation. The results indicate that normal levels of endogenous thyroxine are necessary for normal growth in length and diameter of the duodenum and for normal morphogenesis of previllous ridges and villi. The possibility that adrenocorticoids may also play a role in the normal development of these parameters is indicated, although the evidence is inconclusive.