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An embryological study of a special strain of deformed x‐rayed mice, with special reference to the etiology and morphogenesis of the abnormalities
Author(s) -
Plagens George M.
Publication year - 1933
Publication title -
journal of morphology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 74
eISSN - 1097-4687
pISSN - 0362-2525
DOI - 10.1002/jmor.1050550110
Subject(s) - morphogenesis , biology , strain (injury) , thrombus , pathological , anatomy , embryogenesis , embryology , pathology , embryo , microbiology and biotechnology , genetics , medicine , gene
This investigation consists of an extensive histological study of a special strain of abnormal x‐rayed mice, in an attempt to determine the embryonic origin and development of certain congenital abnormalities that are hereditary. The study shows that development of the x‐rayed strain is normal up to the thirteenth day after insemination, after which pathological structures appear in the form of blebs, hematomas, and thrombi. As a result of the formation of the blebs and hematomas a general condition is set up within the embryo which resembles that of thrombosis. The thrombi when formed exert a mechanical effect by crowding out the normal tissue. A chemical effect is also produced by the blood cells and fluid extravasated from the thrombus which penetrate into the forming tissues resulting in their perverted development. Thus the thrombi are the immediate factors causing the various regions of the body to be deformed.