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Studies on lymphocytes IV. Further observations upon the hemopoietic effects of splenectomy in frogs
Author(s) -
Jordan H. E.,
Speidel C. C.
Publication year - 1925
Publication title -
journal of morphology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 74
eISSN - 1097-4687
pISSN - 0362-2525
DOI - 10.1002/jmor.1050400303
Subject(s) - erythropoiesis , splenectomy , spleen , biology , stimulation , haematopoiesis , bone marrow , anemia , regeneration (biology) , medicine , endocrinology , immunology , microbiology and biotechnology , stem cell
Total splenectomy in the frog means practically complete extirpation of the erythropoietic apparatus. Out of sixty‐four operations it was followed by: 1 Stimulation of erythropoiesis in the kidney (mesonephros), 35 to 46 per cent. 2 Stimulation of erythropoiesis in the fat‐bodies, 5 per cent; lymphocytopoiesis, 8 per cent. 3 Stimulation of erythropoiesis in the bone‐marrow, 11 per cent. 4 Formation of a new spleen, 8 per cent. 5 No perceptible erythropoletic stimulation, 24 per cent. The latter leads to a condition of anemia followed by death within about sixty days.Partial splenectomy leads to spleen regeneration. The life tenure of the frog erythrocyte is approximately 100 days. Total splenectomy experiments indicate that the chief function of the spleen in the frog inheres largely in its lymphocyte content and in the transformation of lymphocytes into erythrocytes.