Open AccessAutoantibodies in Wilson disease: Impact on clinical course
Author(s) -
AntczakKowalska Magdalena,
Członkowska Anna,
Eyileten Ceren,
Palejko Anna,
Cudna Agnieszka,
Wolska Marta,
Piechal Agnieszka,
Litwin Tomasz
Publication year - 2022
Publication title -
jimd reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.412
H-Index - 25
ISSN - 2192-8312
DOI - 10.1002/jmd2.12317
Subject(s) - autoantibody , anti nuclear antibody , antibody , pathogenesis , autoimmunity , immunology , medicine , disease , autoimmune disease , immunofluorescence , pathology
Symptoms of Wilson disease (WD) vary and additional factors such as autoimmunity may play an important role in WD pathogenesis. The presence of antinuclear antibodies (ANA), anti‐neutrophil cytoplasmic antibodies, neuronal surface antibodies, and onconeural antibodies in WD was investigated using standardized indirect immunofluorescence assays and Western Blot analysis. The presence of all studied autoantibodies was higher in WD patients in comparison to healthy subjects, but there was no statistically significant difference in autoantibodies frequency according to disease manifestation. D‐penicillamine treatment was associated with a higher presence of ANA than zinc sulfate but without an increase in autoimmune diseases rate.