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Preparation of isotopically labelled benzophenone‐containing lipid analogues
Author(s) -
Wang Pingzhen,
Spencer Thomas A.
Publication year - 2005
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.996
Subject(s) - benzophenone , chemistry , labelling , sodium borohydride , catalysis , carbon 14 , organic chemistry , combinatorial chemistry , biochemistry , physics , quantum mechanics
Methods have been developed for isotopic labelling of the benzophenone‐containing cholesterol analogue 1 and the fatty acid analogue 2 by use of deuteriated sodium borohydride derivatives. These procedures avoid the commercial catalytic tritiation which had previously been used to obtain 3 H‐ 1 and 3 H‐ 2 . Copyright © 2005 John Wiley & Sons, Ltd.