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Syntheses of deuterated jasmonates for mass spectrometry and metabolism studies
Author(s) -
Galka Patrycja W.,
Ambrose Stephen J.,
Ross Andrew R. S.,
Abrams Suzanne R.
Publication year - 2005
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.994
Subject(s) - chemistry , mass spectrometry , deuterium , metabolism , radiochemistry , biochemistry , chromatography , nuclear physics , physics
Jasmonic acid and its metabolites play an essential role in the regulation of plant development and systemic defense responses. Isotopically labeled standards are required to quantify plant hormones for metabolism studies using mass spectrometry. A convenient method for the preparation of deuterated analogs of jasmonates is demonstrated. Modification of commercially available methyl jasmonate by base‐catalyzed proton/deuterium exchange or Wittig reaction introduces either two or three heavy atoms into a molecule. Copyright © 2005 John Wiley & Sons, Ltd.