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Efficient methods for the synthesis of 5‐(4‐[ 18 F]fluorophenyl)‐10,15,20‐ tris (3‐methoxyphenyl)porphyrin as a potential imaging agent for tumor
Author(s) -
Kavali Rajesh R.,
Chul Lee Byung,
Seok Moon Byung,
Dae Yang Seung,
Soo Chun Kwon,
Woon Choi Chang,
Lee ChangHee,
Yoon Chi Dae
Publication year - 2005
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.992
Subject(s) - chemistry , porphyrin , yield (engineering) , pyrrole , condensation , catalysis , tris , aldehyde , chemical synthesis , combinatorial chemistry , condensation reaction , organic chemistry , nuclear chemistry , biochemistry , materials science , physics , metallurgy , in vitro , thermodynamics
F‐18‐labeled porphyrins, the potential tracing and detecting agents for tumor have been synthesized and characterized by two convenient routes: one is a mixed aldehyde condensation, which involves acid‐catalyzed condensation of pyrrole, m ‐anisaldehyde and 4‐[ 18 F]fluorobenzaldehyde. The other is the acid‐catalyzed condensation of tetrapyrrane with 4‐[ 18 F]fluorobenzaldehyde. The synthetic methodologies including solvents, reaction concentrations and catalysts are optimized for radiolabeled porphyrins. The methods also provide the desired product in reasonable radiochemical yield (20–26%) compared with those of cold chemical synthesis (1–3%) and with high radiochemical purity (>95%). The methods described here would be effective and convenient ways to produce radiolabeled porphyrin. Copyright © 2005 John Wiley & Sons, Ltd.
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