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Synthesis of [ 2 H]‐labelled phase‐I‐metabolites using 1‐[ 2 H]‐pyridinium hydrochloride
Author(s) -
Heinkele Georg,
Mürdter Thomas E.
Publication year - 2005
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.941
Subject(s) - chemistry , pyridinium , demethylation , hydrochloride , reagent , lidocaine hydrochloride , deuterium , organic chemistry , medicinal chemistry , lidocaine , biochemistry , medicine , gene expression , gene , physics , quantum mechanics , anesthesia , dna methylation
Simultaneous O ‐demethylation and hydrogen/deuterium exchange of aryl‐methyl‐ethers can be obtained using 1‐[ 2 H]‐pyridinium hydrochloride as reagent at 220°C for 6 h. This reaction was applied to dextromethorphan and various non‐steroidal anti‐inflammatory drugs. Copyright © 2005 John Wiley & Sons, Ltd.