Synthesis of [ 2 H]‐labelled phase‐I‐metabolites using 1‐[ 2 H]‐pyridinium hydrochloride | Zendy

Heinkele Georg | Zendy; Mürdter Thomas E. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of [ 2 H]‐labelled phase‐I‐metabolites using 1‐[ 2 H]‐pyridinium hydrochloride

Author(s) -

Heinkele Georg,

Mürdter Thomas E.

Publication year - 2005

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.941

Subject(s) - chemistry , pyridinium , demethylation , hydrochloride , reagent , lidocaine hydrochloride , deuterium , organic chemistry , medicinal chemistry , lidocaine , biochemistry , medicine , gene expression , gene , physics , quantum mechanics , anesthesia , dna methylation

Simultaneous O ‐demethylation and hydrogen/deuterium exchange of aryl‐methyl‐ethers can be obtained using 1‐[ 2 H]‐pyridinium hydrochloride as reagent at 220°C for 6 h. This reaction was applied to dextromethorphan and various non‐steroidal anti‐inflammatory drugs. Copyright © 2005 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research