Convenient methods for the synthesis of d 4 , d 2  and d 6  isotopomers of 4‐(4‐fluorobenzyl)piperidine | Zendy

Proszenyák Ágnes | Zendy; Ágai Béla | Zendy; Tárkányi Gábor | Zendy; Vida László | Zendy; Faigl Ferenc | Zendy

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Convenient methods for the synthesis of d 4 , d 2 and d 6 isotopomers of 4‐(4‐fluorobenzyl)piperidine

Author(s) -

Proszenyák Ágnes,

Ágai Béla,

Tárkányi Gábor,

Vida László,

Faigl Ferenc

Publication year - 2005

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.936

Subject(s) - chemistry , piperidine , isotopomers , catalysis , deoxygenation , medicinal chemistry , bromobenzene , pyridine , ring (chemistry) , aldehyde , organic chemistry , molecule

Pure 4‐(4‐fluoro‐[2,3,5,6‐ 2 H 4 ]benzyl)piperidine was prepared via the Grignard reaction of 4‐fluoro‐[2,3,5,6‐ 2 H 4 ]bromobenzene and pyridine‐4‐aldehyde followed by consecutive deoxygenation and heteroatomic ring saturation in the presence of palladium on carbon catalyst. An improved method for the catalytic H/D exchange in benzylic positions of 4‐(4‐fluorobenzyl)piperidine and its d 4 derivative has also been described. Copyright © 2005 John Wiley & Sons, Ltd.

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