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Convenient methods for the synthesis of d 4 , d 2 and d 6 isotopomers of 4‐(4‐fluorobenzyl)piperidine
Author(s) -
Proszenyák Ágnes,
Ágai Béla,
Tárkányi Gábor,
Vida László,
Faigl Ferenc
Publication year - 2005
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.936
Subject(s) - chemistry , piperidine , isotopomers , catalysis , deoxygenation , medicinal chemistry , bromobenzene , pyridine , ring (chemistry) , aldehyde , organic chemistry , molecule
Pure 4‐(4‐fluoro‐[2,3,5,6‐ 2 H 4 ]benzyl)piperidine was prepared via the Grignard reaction of 4‐fluoro‐[2,3,5,6‐ 2 H 4 ]bromobenzene and pyridine‐4‐aldehyde followed by consecutive deoxygenation and heteroatomic ring saturation in the presence of palladium on carbon catalyst. An improved method for the catalytic H/D exchange in benzylic positions of 4‐(4‐fluorobenzyl)piperidine and its d 4 derivative has also been described. Copyright © 2005 John Wiley & Sons, Ltd.