Convenient synthesis of  D ‐ threo ‐[dichloroacetyl 1– 14 C] chloramphenicol | Zendy

Sontakke C. V. | Zendy; Patil S. P. | Zendy; Unny V. K. P. | Zendy; Sivaprasad N. | Zendy

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Convenient synthesis of D ‐ threo ‐[dichloroacetyl 1– 14 C] chloramphenicol

Author(s) -

Sontakke C. V.,

Patil S. P.,

Unny V. K. P.,

Sivaprasad N.

Publication year - 2005

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.932

Subject(s) - chemistry , chloramphenicol , glycine , yield (engineering) , specific activity , chemical synthesis , high performance liquid chromatography , radiochemistry , carbon 14 , chromatography , stereochemistry , nuclear chemistry , organic chemistry , biochemistry , antibiotics , in vitro , amino acid , enzyme , physics , quantum mechanics , materials science , metallurgy

A convenient synthesis of chloramphenicol labelled with carbon‐14 in the dichloroacetyl group at the 1 position is described. It was prepared as part of a 4‐step sequence from [1 ‐ 14 C] glycine and the product was purified by preparative HPLC. A radiochemical yield of 47% was obtained based on [1 ‐ 14 C] glycine and the product had a specific activity of 0.47 mCi/mmol. The procedure can be employed for the synthesis of high specific activity [ 14 C] chloramphenicol, labelled at 1, 2 or both the positions of dichloroacetyl group. Copyright © 2005 John Wiley & Sons, Ltd.

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