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The mediation of aryl ketone deuteration by [Ir(PPh 3 ) 3 (cod)] + .BF 4 −
Author(s) -
Herbert John M.
Publication year - 2005
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.925
Subject(s) - chemistry , aryl , ketone , mediation , medicinal chemistry , stereochemistry , organic chemistry , alkyl , political science , law
The usefulness of the hydrogen isotope exchange catalyst, [Ir(PPh 3 ) 3 (cod)] + .BF 4 − (1), is explored. It appears that isotopic exchange mediated by 1 occurs via a series of complexes in which all three phosphine ligands are retained. The disadvantage of this system is that the catalytic intermediates are necessarily sterically hindered, with the result that the range of substrates for which the system is effective is small. Copyright © 2005 John Wiley & Sons, Ltd.