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Synthesis of an iodine‐123‐labeled celecoxib analogue: a potential spect agent
Author(s) -
Kabalka George W.,
Mereddy Arjun R.,
Schuller Hildegard M.
Publication year - 2005
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.923
Subject(s) - celecoxib , chemistry , iodine 123 , iodine , cyclooxygenase , trifluoromethyl , pharmacology , radiochemistry , combinatorial chemistry , nuclear medicine , organic chemistry , enzyme , biochemistry , medicine , alkyl
Celecoxib (4‐[5‐(4‐methylphenyl)‐3‐(trifluoromethyl)‐1H‐pyrazol‐1yl]‐benzenesulfonamide) is an effective inhibitor of the cyclooxygenase‐2 (COX‐2). The synthesis of a no‐carrier‐added iodine‐123‐labeled analogue of celecoxib was accomplished in four steps for potential use in single photon tomography. Copyright © 2005 John Wiley & Sons, Ltd.