Synthesis of an iodine‐123‐labeled celecoxib analogue: a potential spect agent | Zendy

Kabalka George W. | Zendy; Mereddy Arjun R. | Zendy; Schuller Hildegard M. | Zendy

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Synthesis of an iodine‐123‐labeled celecoxib analogue: a potential spect agent

Author(s) -

Kabalka George W.,

Mereddy Arjun R.,

Schuller Hildegard M.

Publication year - 2005

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.923

Subject(s) - celecoxib , chemistry , iodine 123 , iodine , cyclooxygenase , trifluoromethyl , pharmacology , radiochemistry , combinatorial chemistry , nuclear medicine , organic chemistry , enzyme , biochemistry , medicine , alkyl

Celecoxib (4‐[5‐(4‐methylphenyl)‐3‐(trifluoromethyl)‐1H‐pyrazol‐1yl]‐benzenesulfonamide) is an effective inhibitor of the cyclooxygenase‐2 (COX‐2). The synthesis of a no‐carrier‐added iodine‐123‐labeled analogue of celecoxib was accomplished in four steps for potential use in single photon tomography. Copyright © 2005 John Wiley & Sons, Ltd.

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