An improved bidentate complex of iridium as a catalyst for hydrogen isotope exchange | Zendy

Herbert John M. | Zendy; Kohler Andrew D. | Zendy; McNeill Alan H. | Zendy

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An improved bidentate complex of iridium as a catalyst for hydrogen isotope exchange

Author(s) -

Herbert John M.,

Kohler Andrew D.,

McNeill Alan H.

Publication year - 2005

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.921

Subject(s) - chemistry , iridium , catalysis , hydrogen isotope , denticity , hydrogen , radiochemistry , inorganic chemistry , organic chemistry , metal

Iridium(I) complexes 1 , containing bidentate phosphines, and 3 , with arsine ligands, are generated in situ. These species mediate hydrogen isotope exchange in a variety of aromatic substrates including benzyl ketones. Although the catalytic activities of complexes 1 and 3 are generally unexceptional, a logical step leads to the use of [ethylene‐1,2‐ bis (diphenylarsine)](cyclooctadiene)iridium(I) tetrafluoroborate ( 5 ), which is an efficient catalyst for both aryl and benzyl ketones, and mediates exchange to a substantial extent in other substrates also. Copyright © 2005 John Wiley & Sons, Ltd.

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