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An improved bidentate complex of iridium as a catalyst for hydrogen isotope exchange
Author(s) -
Herbert John M.,
Kohler Andrew D.,
McNeill Alan H.
Publication year - 2005
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.921
Subject(s) - chemistry , iridium , catalysis , hydrogen isotope , denticity , hydrogen , radiochemistry , inorganic chemistry , organic chemistry , metal
Iridium(I) complexes 1 , containing bidentate phosphines, and 3 , with arsine ligands, are generated in situ. These species mediate hydrogen isotope exchange in a variety of aromatic substrates including benzyl ketones. Although the catalytic activities of complexes 1 and 3 are generally unexceptional, a logical step leads to the use of [ethylene‐1,2‐ bis (diphenylarsine)](cyclooctadiene)iridium(I) tetrafluoroborate ( 5 ), which is an efficient catalyst for both aryl and benzyl ketones, and mediates exchange to a substantial extent in other substrates also. Copyright © 2005 John Wiley & Sons, Ltd.