Synthesis of labelled  N ‐(4‐hydroxy‐[ 14 C(U)]phenyl)‐2‐[2,3‐dihydro‐3‐oxo‐l,2‐benzisothiazol‐2‐yl‐1,1‐dioxide]acetamide | Zendy

Xu Liang | Zendy; Trudell Mark L. | Zendy

Premium

Synthesis of labelled N ‐(4‐hydroxy‐[ 14 C(U)]phenyl)‐2‐[2,3‐dihydro‐3‐oxo‐l,2‐benzisothiazol‐2‐yl‐1,1‐dioxide]acetamide

Author(s) -

Xu Liang,

Trudell Mark L.

Publication year - 2005

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.909

Subject(s) - chemistry , acetamide , yield (engineering) , hydrolysis , phenol , medicinal chemistry , aqueous solution , carbon dioxide , chloride , nuclear chemistry , organic chemistry , metallurgy , materials science

The amidation of 2‐[1,1‐dioxide‐3‐oxo‐1,2‐benzisothiazole‐2(3H)‐yl] acetyl chloride with carbon‐14‐labelled 4‐amino‐[ 14 C(U)]phenol in NaOAc‐HOAc buffer solution at −10°C gave N ‐(4‐hydroxy‐[ 14 C(U)]phenyl)‐2‐[2,3‐dihydro‐3‐oxo‐1,2‐benziso‐thiazol‐2‐yl‐1,1‐dioxide]acetamide in 82% yield. Subsequent hydrolysis with aqueous 0.5 N NaOH solution afforded the ring opened product N ‐(4‐hydroxy‐[ 14 C(U)]‐phenyl)‐2‐[2‐carboxy‐phenylsulfonamido]acetamide in 80% yield. Copyright © 2005 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research