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Synthesis of 13 C 6 ‐labeled Reyataz™ (BMS‐232632)
Author(s) -
Burrell Richard C.,
Lago Michael W.,
Luke George M.,
Rinehart J. Kent
Publication year - 2005
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.905
Subject(s) - chemistry , yield (engineering) , phenylalanine , ring (chemistry) , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , amino acid , materials science , metallurgy
An efficient synthesis of 13 C 6 ‐labeled Reyataz™ (BMS‐232632) is described. 13 C 6 ‐labeled Reyataz™ was synthesized in eight steps from commercially available [ ring ‐ 13 C 6 ]‐ L ‐phenylalanine. The overall yield of the synthesis was 8% and the purity of the final product was greater than 98%. Copyright © 2005 John Wiley & Sons, Ltd.
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