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Synthesis of tritium labelled [2′,6′]‐ L ‐tyrosine
Author(s) -
Augustyniak W.,
Kański R.,
Kańska M.
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.886
Subject(s) - chemistry , tritium , citrobacter freundii , phenol , isotopomers , tyrosinase , tritiated water , enzyme , specific activity , chemical synthesis , catalysis , tyrosine , organic chemistry , radiochemistry , biochemistry , enterobacteriaceae , physics , escherichia coli , molecule , nuclear physics , in vitro , gene
The synthesis of a specifically ring labelled isotopomer of L ‐tyrosine, ( L ‐Tyr), using a combination of chemical and enzymatic methods is reported. The tritium labelled [2′,6′]‐ L ‐Tyr has been synthesized via catalytic exchange of phenol with tritiated water in the presence of K 2 PtCl 4 , reverse acid catalysed removal of tritium from the o ‐ and p ‐positions of phenol, and subsequent condensation of the resulting [3′,5‐ 3 H 2 ]‐phenol with S ‐methyl‐ L ‐cysteine using the enzyme β ‐tyrosinase from Citrobacter freundii . Copyright © 2004 John Wiley & Sons, Ltd.
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