Synthesis of [ O ‐methyl‐ 11 C]‐4‐(1,3‐dimethoxy‐2‐propylamino)‐2,7‐dimethyl‐8‐(2,4‐dichlorophenyl)[1,5‐a]pyrazolo‐1,3,5‐triazine ([ 11 C]DMP696): a potential PET ligand for CRF 1  receptors | Zendy

Kumar J. S. Dileep | Zendy; Majo Vattoly J. | Zendy; Simpson Norman R. | Zendy; Prabhakaran Jaya | Zendy; Van Heertum Ronald L. | Zendy; Mann J. John | Zendy

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Synthesis of [ O ‐methyl‐ 11 C]‐4‐(1,3‐dimethoxy‐2‐propylamino)‐2,7‐dimethyl‐8‐(2,4‐dichlorophenyl)[1,5‐a]pyrazolo‐1,3,5‐triazine ([ 11 C]DMP696): a potential PET ligand for CRF 1 receptors

Author(s) -

Kumar J. S. Dileep,

Majo Vattoly J.,

Simpson Norman R.,

Prabhakaran Jaya,

Van Heertum Ronald L.,

Mann J. John

Publication year - 2004

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.885

Subject(s) - chemistry , trifluoromethanesulfonate , yield (engineering) , triazine , chemical synthesis , medicinal chemistry , d 1 , stereochemistry , organic chemistry , receptor , catalysis , in vitro , biochemistry , materials science , metallurgy

Synthesis of [ O ‐methyl‐ 11 C]‐4‐(1,3‐dimethoxy‐2‐propylamino)‐2,7‐dimethyl‐8‐(2,4‐dichlorophenyl)[1,5‐a]pyrazolo‐1,3,5‐triazine ([ 11 C]DMP696), a highly selective CRF 1 antagonist has been achieved. The total time required for the synthesis of [ 11 C]DMP696 is 30 min from EOB using [ 11 C]methyl triflate in THF, with a 16% yield (EOS) and >99% chemical and radiochemical purities along with a specific activity of >2000 Ci/mmol (EOS). Copyright © 2004 John Wiley & Sons, Ltd.

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