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Utility of azetidinium methanesulfonates for radiosynthesis of 3‐[ 18 F]fluoropropyl amines
Author(s) -
Kiesewetter Dale O.,
Eckelman William C.
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.884
Subject(s) - radiosynthesis , chemistry , radiochemistry , combinatorial chemistry , microbiology and biotechnology , biology , in vivo
3‐Methanesulfonyloxypropyl tertiary amines were observed to cyclize to form azetidinium methanesulfonate moieties. Heat‐induced cyclization of 3‐methanesulfonyloxypropyl amines was utilized for preparation of azetidinium methanesulfonates. The azetidinium methanesulfonates were found to incorporate radioactive [ 18 F]fluoride (decay‐corrected yields >60%) efficiently, resulting in an efficient synthesis of 3‐[ 18 F]fluoropropyl tertiary amines. Copyright © 2004 John Wiley & Sons, Ltd.