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Microwave‐enhanced, solvent‐free synthesis of singly and doubly 13 C‐labelled trans ‐cinnamic acid at the α ‐ and β ‐carbon positions
Author(s) -
Ma Guibin,
Hayes Sophia E.
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.878
Subject(s) - chemistry , cinnamic acid , benzaldehyde , malonic acid , microwave irradiation , solvent , ammonium acetate , carbon 14 , ammonium , organic chemistry , carbon fibers , medicinal chemistry , nuclear chemistry , catalysis , high performance liquid chromatography , physics , materials science , quantum mechanics , composite number , composite material
13 C‐labelled trans ‐cinnamic acid (3‐phenyl‐2‐propenoic acid) has been synthesized in one step using benzaldehyde‐carbonyl‐ 13 C and malonic acid‐2‐ 13 C in the presence of ammonium acetate under microwave irradiation and solvent‐free conditions. Copyright © 2004 John Wiley & Sons, Ltd.