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Synthesis of carbon‐14 labelled gemifloxacin
Author(s) -
Shin Hyun Il,
Rim Jong Gill,
Lee Ki Seung,
Kim Young Seok,
Nam Do Hyun,
Shin Hyun Ik,
Chang Jay Hyok,
Oh Chang Young,
Ham Won Hun
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.866
Subject(s) - gemifloxacin , chemistry , quinolone , yield (engineering) , carbon 14 , pharmacokinetics , sodium acetate , ring (chemistry) , radiochemistry , nuclear chemistry , antibacterial agent , combinatorial chemistry , organic chemistry , antibiotics , pharmacology , biochemistry , materials science , medicine , physics , quantum mechanics , metallurgy
A new antibacterial agent gemifloxacin was labelled with carbon‐14 for studies of pharmacokinetics and metabolism, the label was located in position 3 of the quinolone ring system. The overall radiochemical yield of the 14‐step synthesis, starting from [2‐ 14 C]sodium acetate was 16.6%, and the radiochemical purity 97.5%. Copyright © 2004 John Wiley & Sons, Ltd.