Synthesis of carbon‐14 labelled gemifloxacin | Zendy

Shin Hyun Il | Zendy; Rim Jong Gill | Zendy; Lee Ki Seung | Zendy; Kim Young Seok | Zendy; Nam Do Hyun | Zendy; Shin Hyun Ik | Zendy; Chang Jay Hyok | Zendy; Oh Chang Young | Zendy; Ham Won Hun | Zendy

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Synthesis of carbon‐14 labelled gemifloxacin

Author(s) -

Shin Hyun Il,

Rim Jong Gill,

Lee Ki Seung,

Kim Young Seok,

Nam Do Hyun,

Shin Hyun Ik,

Chang Jay Hyok,

Oh Chang Young,

Ham Won Hun

Publication year - 2004

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.866

Subject(s) - gemifloxacin , chemistry , quinolone , yield (engineering) , carbon 14 , pharmacokinetics , sodium acetate , ring (chemistry) , radiochemistry , nuclear chemistry , antibacterial agent , combinatorial chemistry , organic chemistry , antibiotics , pharmacology , biochemistry , materials science , medicine , physics , quantum mechanics , metallurgy

A new antibacterial agent gemifloxacin was labelled with carbon‐14 for studies of pharmacokinetics and metabolism, the label was located in position 3 of the quinolone ring system. The overall radiochemical yield of the 14‐step synthesis, starting from [2‐ 14 C]sodium acetate was 16.6%, and the radiochemical purity 97.5%. Copyright © 2004 John Wiley & Sons, Ltd.

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