Uncatalyzed microwave deuterium exchange labeling of bleomycin A 2 | Zendy

de Keczer Steve A. | Zendy; Lane Tim S. | Zendy; Masjedizadeh Mohammad R. | Zendy

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Uncatalyzed microwave deuterium exchange labeling of bleomycin A 2

Author(s) -

de Keczer Steve A.,

Lane Tim S.,

Masjedizadeh Mohammad R.

Publication year - 2004

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.857

Subject(s) - chemistry , deuterium , hydrogen–deuterium exchange , imidazole , bleomycin , microwave , thiazole , catalysis , quinazoline , radiochemistry , nuclear chemistry , organic chemistry , mass spectrometry , chromatography , nuclear physics , medicine , physics , surgery , chemotherapy , quantum mechanics

Bleomycin sulfate in D 2 O was deuterated using microwave irradiation under catalyst free conditions. Following the removal of labile deuterium and purification, bleomycin A 2 with mass M + 1 to M + 7 was obtained. Successful selective uncatalyzed microwave deuterium exchange reactions on examples from the following classes of heterocycles are also described: imidazole, thiazole, indole, purine, and quinazoline. The described method was used as a test for non‐labile active protons. Copyright © 2004 John Wiley & Sons, Ltd.

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