z-logo
Premium
Uncatalyzed microwave deuterium exchange labeling of bleomycin A 2
Author(s) -
de Keczer Steve A.,
Lane Tim S.,
Masjedizadeh Mohammad R.
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.857
Subject(s) - chemistry , deuterium , hydrogen–deuterium exchange , imidazole , bleomycin , microwave , thiazole , catalysis , quinazoline , radiochemistry , nuclear chemistry , organic chemistry , mass spectrometry , chromatography , nuclear physics , medicine , physics , surgery , chemotherapy , quantum mechanics
Bleomycin sulfate in D 2 O was deuterated using microwave irradiation under catalyst free conditions. Following the removal of labile deuterium and purification, bleomycin A 2 with mass M + 1 to M + 7 was obtained. Successful selective uncatalyzed microwave deuterium exchange reactions on examples from the following classes of heterocycles are also described: imidazole, thiazole, indole, purine, and quinazoline. The described method was used as a test for non‐labile active protons. Copyright © 2004 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here