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Synthesis and characterization of 99m Tc‐labelled biologically active molecules using borohydride exchange resin as a reducing agent for the preparation of radiopharmaceuticals
Author(s) -
Park Sang Hyun,
Gwon Hui Jeong,
Park Kyung Bae
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.856
Subject(s) - chemistry , borohydride , reducing agent , pertechnetate , combinatorial chemistry , labelling , molecule , ligand (biochemistry) , radiochemistry , biological activity , specific activity , nuclear chemistry , organic chemistry , technetium , catalysis , in vitro , biochemistry , receptor , enzyme
A novel and efficient method for preparing 99m Tc‐complexes of radiopharmaceuticals has been developed by reacting [ 99m Tc]pertechnetate with a ligand in the presence of borohydride exchange resin (BER) as a reducing agent. The latter is stable over a wide range of pH (2–11) and thus can be used with biologically active compounds without the formation of insoluble 99m TcO 2 or SnO 2 colloids. Since the radiolabelled complexes are produced with high radiochemical purity and labelling efficiency under milder conditions than those required for the conventional reducing agents, the latter can be replaced. The method is expected to be applicable to the preparation of 99m Tc‐radiopharmaceuticals. Copyright © 2004 John Wiley & Sons, Ltd.