Synthesis of  2 H‐ and  3 H‐labelled iptakalim hydrochloride | Zendy

Zhang Cheng | Zendy; Yang Rifang | Zendy; Chen Lanfu | Zendy; Zhong Bohua | Zendy; Yun Liuhong | Zendy; Wang Hai | Zendy

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Synthesis of 2 H‐ and 3 H‐labelled iptakalim hydrochloride

Author(s) -

Zhang Cheng,

Yang Rifang,

Chen Lanfu,

Zhong Bohua,

Yun Liuhong,

Wang Hai

Publication year - 2004

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.844

Subject(s) - chemistry , derivatization , hydrochloride , pharmacology , chemical synthesis , chromatography , combinatorial chemistry , organic chemistry , high performance liquid chromatography , biochemistry , in vitro , medicine

Iptakalim hydrochloride ( N ‐(1‐methylethyl)‐1,1,2‐trimethyl‐propylamine hydrochloride) is a promising antihypertensive drug discovered and developed by Beijing Institute of Pharmacology and Toxicology. Deuterium‐ and tritium‐labelled compounds were designed and synthesized for pharmacokinetic and pharmacological mechanism studies. A derivatization method has been employed in the synthesis procedure. Copyright © 2004 John Wiley & Sons, Ltd.

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