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Synthesis of 2 H‐ and 3 H‐labelled iptakalim hydrochloride
Author(s) -
Zhang Cheng,
Yang Rifang,
Chen Lanfu,
Zhong Bohua,
Yun Liuhong,
Wang Hai
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.844
Subject(s) - chemistry , derivatization , hydrochloride , pharmacology , chemical synthesis , chromatography , combinatorial chemistry , organic chemistry , high performance liquid chromatography , biochemistry , in vitro , medicine
Iptakalim hydrochloride ( N ‐(1‐methylethyl)‐1,1,2‐trimethyl‐propylamine hydrochloride) is a promising antihypertensive drug discovered and developed by Beijing Institute of Pharmacology and Toxicology. Deuterium‐ and tritium‐labelled compounds were designed and synthesized for pharmacokinetic and pharmacological mechanism studies. A derivatization method has been employed in the synthesis procedure. Copyright © 2004 John Wiley & Sons, Ltd.